Brain-derived neurotrophic factor (BDNF) (rs6265) may, potentially, be an indicator of susceptibility for tinnitus distress (Vanneste et al. 2021), and the catecholo-methyl-transferase (COMT) polymorphism may be associated with tinnitus loudness (Vanneste et al. 2018). This evidence concerns the gene BDNF and Tinnitus.