Leukemia inhibitory factor is a pleiotropic and significant cytokine involved in a wide variety of activities such as regulating the growth and differentiation of leukemia and hematopoietic cells, stem cell self-renewal, embryo implantation, inflammatory responses, and cancer progression[1], [2], [3], [4], [5], [6], [7], [8], [9]. The gene discussed is LIF; the disease is cancer.