Cluster 1 was more heterogenous and lacked a distinct transcriptional profile, whereas Type I IFN (Isg15, Ifi206, Ifit3, Ccl5) and proliferative signatures (Cdk1, Mki67, Tuba1b) were observed in clusters 3 and 5, respectively (Figure 3F), whose numbers remained stable between days 7 and 14 after infection (Figure 3E). This evidence concerns the gene ISG15 and infection.