Similar to microglia and monocytes/macrophages, the Dendritic 1 cluster in Rag1–/– mice had significant reductions in Type I and Type II IFN responses, IL-1 production, AIM2 inflammasome, and Ag presentation pathways primarily at day 7 after infection (Supplemental Figure 10, B and C). The gene discussed is RAG1; the disease is infection.