Similar findings were observed with leukocyte infiltrates, where monocyte, G-MDSC, and PMN recruitment to the brain was restored to WT levels when Rag1–/– mice received Th1 or Th17 cells at day 3 (Figure 5C) but were less effective when adoptive transfer was initiated at day 7 after infection (Figure 5D). The gene discussed is RAG1; the disease is infection.