We found that, in all analyzed participants regardless of the stratification by infection history, the DENV-specific CD4+ T cells were predominantly composed of effector memory T (Tem) cells (CD45RA−CCR7−), followed by central memory T (Tcm) cells (CD45RA−CCR7+), and then the T effector memory reexpressing CD45RA (Temra) subset (CCR7+CD45RA+), which was the smallest subset. Here, CD4 is linked to infection.