Similar to NL and NXG, sarcoidosis lesional macrophages upregulated expression of the macrophage polarization marker genes MARCO, FCGR3A, NR1H3; the ECM-encoding gene FN1; the protease-encoding gene CTSS; and genes associated with inflammation, S100A8 and CHI3L1 (Supplemental Figure 10A). The gene discussed is CTSS; the disease is sarcoidosis.