While the specific cytotoxic target of NKG7 T cells in necrobiosis remains undetermined, scRNA-seq revealed that these cells are likely contributing to NL and NXG pathophysiology via their secretion of inflammatory cytokines, notably, CCL5, IFNG, and IL32 (Figure 6E and Supplemental Figure 11). Here, IFNG is linked to necrobiotic xanthogranuloma.