This analysis revealed either poor expression or very modest increases in MMP9, CCL5, CXCL9, IL32, CD74, COL4A4, COL8A1, and COL11A1 in systemic sclerosis fibroblasts, unlike their observed expression pattern in NL lesional CCL5hi fibroblasts. The gene discussed is COL8A1; the disease is systemic sclerosis.