When exploring mean expression of genes differentially expressed between CLAD, IPF, and control lungs and HLNs, we found a consistent pattern of CLAD lungs and HLNs showing relative upregulation of genes encoding cytolytic enzymes (GZMA, GZMB, GZMH, and GZMM) as well as pore formation for delivery of these enzymes (PRF1) and cytolytic granule degranulation (LAMP1). Here, PRF1 is linked to idiopathic pulmonary fibrosis.