Differential associations of hippocampal volume (HV), 18F‐fluorodeoxyglucose positron emission tomography (FDG PET) standardized uptake value ratios (SUVRs), and plasma neurofilament light chain (NfL) levels with amyloid beta (Aβ)–tau pathology and cognitive impairment were examined. Here, MAPT is linked to Cognitive impairment.