This may be attributed to the fact that the previous hypothesis was not directly derived from the effects of brain Aβ and tau on various indicators of N. Instead, it was primarily concluded from the observations related to these indicators in differentiating various cognitive stages, predicting cognitive decline, as well as their prevalence of abnormalities and rates of change during disease progression.24, 25, 26, 27. Here, MAPT is linked to Mental deterioration.