Since valve interstitial cells are a specialized type of fibroblast [78–81], it would be worthwhile to investigate if SQSTM1-mediated CDKN2A and CDKN1A selective autophagy has fibroblast specificity, not least since senescent transformation contributes to many the pathological changes in many age-related diseases, such as kidney fibrosis, atherosclerosis and skin aging [80,82,83]. The gene discussed is CDKN2A; the disease is atherosclerosis.