NFKB1 and neoplasm: In addition, we also demonstrated that HY-P1860, an activator of NF-κB signaling pathway, can promote tumor cell proliferation and CBX7 can inhibit its pro-cancer effect through in vitro and in vivo experiments, indicating that CBX7 plays a biological role in tumor suppression by inhibiting activation of the NF-κB signaling pathway (Fig. 5G, H).