Sixteen target genes associated with biochemical recurrence of prostate cancer were further screened out by Lasso regression, including MAN1C1, CTBS, LAMC1, DEGS1, TRNT1, DHX30, FSTL1, EIF4G1, FAM50B, GRB10, SPTBN2, NADSYN1, SYTL2, NAGLU, SERPINB5, and PRDM15 (Fig. 6D, E). The gene discussed is DHX30; the disease is Familial prostate cancer.