Sixteen target genes associated with biochemical recurrence of prostate cancer were further screened out by Lasso regression, including MAN1C1, CTBS, LAMC1, DEGS1, TRNT1, DHX30, FSTL1, EIF4G1, FAM50B, GRB10, SPTBN2, NADSYN1, SYTL2, NAGLU, SERPINB5, and PRDM15 (Fig. 6D, E). The gene discussed is MAN1C1; the disease is prostate cancer.