Sixteen target genes associated with biochemical recurrence of prostate cancer were further screened out by Lasso regression, including MAN1C1, CTBS, LAMC1, DEGS1, TRNT1, DHX30, FSTL1, EIF4G1, FAM50B, GRB10, SPTBN2, NADSYN1, SYTL2, NAGLU, SERPINB5, and PRDM15 (Fig. 6D, E). Here, DEGS1 is linked to Familial prostate cancer.