Based on the functional data and the enrichment in patients with an odds ratio for PD of 8.0, the ACMG PS3 criterion for “strong” evidence of pathogenicity of the p.Arg1067Gln variant is fulfilled23 and the LRRK2 p.Arg1067Gln variant should be reclassified as pathogenic. The gene discussed is LRRK2; the disease is Parkinson disease.