Here, we aimed to decipher the pathogenicity of the LRRK2 p.Arg1067Gln (p.R1067Q) variant (NM_198578.4, rs111341148, c.3200G>A), which authors have usually classified as a VUS15–22, by leveraging on large datasets of Malaysian, Singaporean, and mainland Chinese PD patients, and using a recently established analytic workflow to determine kinase activity of individual LRRK2 variants in vitro and in vivo6,23. Here, LRRK2 is linked to Parkinson disease.