LRRK2 and tauopathy: Pleiotropy with pathogenic LRRK2 variants (e.g., p.Gly2019Ser, p.Arg1441Cys) has been recognized with, for example, isolated cases exhibiting clinical9,46 and/or pathological features of tauopathy/PSP4,47,48 and a substantial proportion lacking evidence of alpha-synucleinopathy49,50.