In the abovementioned study by Desai et al., IDH1, IDH2, TP53, DNMT3A, TET2 and spliceosome genes such as U2AF1, SF3B1 and SRSF2 mutations significantly increased risk of progression to AML on multivariable analysis correcting for potential confounders such as age and presence of comutations [54]. This evidence concerns the gene DNMT3A and acute myeloid leukemia.