In the aforementioned case-control study by Abelson et al., clonal haematopoiesis involving the genes TP53, IDH1 and IDH2, SRSF2, SF3B1 and U2AF1 with VAF > 0.01 was shown to increase risk of AML development [55]. This evidence concerns the gene SRSF2 and acute myeloid leukemia.