In the aforementioned case-control study by Abelson et al., clonal haematopoiesis involving the genes TP53, IDH1 and IDH2, SRSF2, SF3B1 and U2AF1 with VAF > 0.01 was shown to increase risk of AML development [55]. The gene discussed is SF3B1; the disease is acute myeloid leukemia.