Interestingly, all individuals with TP53 (n = 21), and IDH1 or IDH2 (n = 15) gene mutations developed AML in the study by Desai et al. [54] However, it is difficult to extrapolate such a finding to the general population given the study by Desai et al. only included female subjects. This evidence concerns the gene IDH2 and acute myeloid leukemia.