STUB1 and atherosclerosis: CHIP was also a risk factor for atherosclerosis across multiple vascular beds, with significant associations for aortic aneurysms (HR 1.74, 1.21–2.51), other aneurysms (HR 1.70, 1.20–1.63), and mesenteric ischemia (HR 3.22, 2.01–5.17) [48].