Body weight exhibited the highest mediation at 30.3% (95% CI: 3.85%-56.75%), followed by IL-17 (17.2%; 95% CI: 2.01%-38.78%), TNF (14.08%; 95% CI: 2.23%-35.10%), coronary atherosclerosis (13.4%; 95% CI: 4.89%-23.98%), and hypertension (11.6%; 95% CI: 2.45%-21.51%). The gene discussed is TNF; the disease is coronary atherosclerosis.