NPPB and heart failure: A subanalysis of the Prospective Comparison of ARNI with ACEI to Determine Impact on Global Mortality and Morbidity in Heart Failure (PARADIGM-HF) study showed that patients with a large decreases in NT-proBNP after Sac/Val exhibit modest decreases in BNP and good prognoses, while patients with modest increases in NT-proBNP after Sac/Val treatment exhibit large increases in BNP after Sac/Val and poor prognoses.12