SNCA and Parkinson disease: Synucleinopathies, including Parkinson’s disease (PD), Dementia with Lewy Bodies (DLB), Multiple systems atrophy (MSA), pure autonomic failure and REM sleep behavior disorder (RBD), are neurodegenerative disorders that share a common feature of aberrant accumulation of alpha-synuclein (aSyn) aggregates in the brain1–3, which may be underlying the mechanisms of pathogenesis via aSyn spreading4–6.