Before SII reaches 6.410, log SII is positively correlated with obesity risk, with an OR value of 1.702(1.445–2.093), suggesting that as SII increases and systemic inflammation intensifies, adipokines and pro-inflammatory cytokines released by macrophages may impair insulin signaling pathways and induce insulin resistance, driving the onset of obesity and its complications16. The gene discussed is INS; the disease is obesity due to melanocortin 4 receptor deficiency.