In glioblastoma (GBM) stem cells, METTL3 and YTHDF2 have been implicated in Yin Yang 1 (YY1)-mediated IFN-β signaling and antigen presentation through m6A methylation, reducing Treg cell infiltration and improving the efficacy of immune checkpoint therapy [98]. The gene discussed is YY1; the disease is glioblastoma.