YTHDF1 and metabolic dysfunction-associated steatohepatitis: Utilizing single-cell RNA sequencing, Wang et al. and colleagues demonstrated that YTHDF1 promotes the accumulation of MDSCs and suppresses cytotoxic CD8 + T cell function in the tumor tissues of spontaneous non-alcoholic steatohepatitis-associated hepatocellular carcinoma (NASH-HCC) models [99].