In CRC models, ALKBH5 promotes the accumulation of MDSCs while reducing NK cells and cytotoxic CD8 + T cells, facilitating tumorigenesis via the Wnt/β-catenin/DKK1 axis by downregulating Wnt suppressor AXIN2 through m6A RNA demethylation [141]. Here, ALKBH5 is linked to colorectal carcinoma.