IFNG and neoplasm: Loss of YTHDF1 has been shown to mediate overexpression of IFN-γ receptor 1 (IFNGR1) in GC cells, enhancing the IFN-γ response and promoting the expression of major histocompatibility complex class I (MHC-I) on tumor cells, facilitating the presentation of immunogenic tumor cells to cytotoxic T lymphocytes (CTLs) and triggering strong antitumor responses [93].