BHLHE41 and colorectal cancer: In colorectal cancer (CRC), knockdown of METTL3 disrupted the m6A-dependent basic helix-loop-helix family member e41 (BHLHE41)-CXCL1 axis, leading to reduced accumulation of MDSCs, while promoting sustained activation and proliferation of CD4 + and CD8 + T cells, ultimately suppressing CRC progression [101].