Overexpression of YTHDF1 enhanced the translation of p65 in CRC cells in an m6A-dependent manner, with the YTHDF1/p65 axis upregulating MDSC migration via the CXCL1-CXCR2 axis, thereby antagonizing functional CD8 + T cells [104]. Here, YTHDF1 is linked to colorectal carcinoma.