Utilizing single-cell RNA sequencing, Wang et al. and colleagues demonstrated that YTHDF1 promotes the accumulation of MDSCs and suppresses cytotoxic CD8 + T cell function in the tumor tissues of spontaneous non-alcoholic steatohepatitis-associated hepatocellular carcinoma (NASH-HCC) models [99]. This evidence concerns the gene YTHDF1 and hepatocellular carcinoma.