Silencing or inactivating ALKBH5 in GBM cells significantly reduced hypoxia-induced recruitment of TAMs and immunosuppression by regulating the m6A- lncRNA NEAT1-splicing factor proline and glutamine rich (SFPQ)-CXCL8/IL8 signaling pathway [102]. The gene discussed is CXCL8; the disease is glioblastoma.