CD274 and non-small cell lung carcinoma: In non-small-cell lung cancer (NSCLC), ALKBH5 mediated m6A modification of JAK2 mRNA, activated the JAK2/p-STAT3/CCL2/CXCL10 axis, leading to the recruitment of PD-L1 + TAMs and promoting M2 macrophage polarization [103].