In non-small-cell lung cancer (NSCLC), ALKBH5 mediated m6A modification of JAK2 mRNA, activated the JAK2/p-STAT3/CCL2/CXCL10 axis, leading to the recruitment of PD-L1 + TAMs and promoting M2 macrophage polarization [103]. The gene discussed is STAT3; the disease is non-small cell lung carcinoma.