Jin et al. uncovered a novel ALKBH5/RIG-I/IFN-α axis, demonstrating that m6A-dependent binding of HNRNPC to DDX58 mRNA (which encodes RIG-I) promotes tumor immune evasion in head and neck squamous cell carcinoma (HNSCC) by facilitating immune escape [96]. Here, RIGI is linked to head and neck squamous cell carcinoma.