Overexpression of YTHDF1 enhanced the translation of p65 in CRC cells in an m6A-dependent manner, with the YTHDF1/p65 axis upregulating MDSC migration via the CXCL1-CXCR2 axis, thereby antagonizing functional CD8 + T cells [104]. The gene discussed is CXCL1; the disease is colorectal carcinoma.