To confirm that the efficacy of ATO is associated with the rescue of p53-R279W, tumors were isolated from ATO-treated and untreated W/W mice; immunoblotting showed that T-lymphomas, S-lymphomas, and sarcomas expressed upregulated Cdkn1a and Mdm2 in ATO-treated mice (Figure 1L). This evidence concerns the gene CDKN1A and sarcoma.