In this issue of FUNCTION, Otterpohl and colleagues8 report progressive renal failure due to tubulointerstitial fibrosis, immune cell infiltration, and tubular injury in mice with conditional deletion of Myh9/Myh10 under control of the Umod promoter (Myh9/Myh10 TAL-cKO). The gene discussed is MYH9; the disease is acute kidney injury.