Using an ELISA cut-off value of 10,000 IU/mL for neurological disease as previously suggested (11), 17/153 (11%) of ‘diabetes only’ and 15/70 (21%) OND patients would be included in the ‘relevant neurological disease’ group whilst 34/87 (39%) patients with ‘classical’ GAD-Ab related syndromes were excluded. This evidence concerns the gene GAD1 and nervous system disorder.