Of note, while monocytes were also slightly increased in the initial stages of infection, we have observed a shift from the classical (Ly6C+, CD43-) to intermediate (Ly6C + CD43+) and non-classical (Ly6Clow, CD43+) monocyte phenotypes over the course of intranasal infection (Meghraoui-Kheddar et al. 2020). The gene discussed is SPN; the disease is infection.