For example, lenvatinib inhibits VEGF- and FGF-stimulated tube formation in human umbilical vein endothelial cells (HUVECs) in an in vitro tube formation assay and lenvatinib significantly reduces VEGF- and FGF-induced tumor vasculature formation in an in vivo dorsal air sac assay [25]. The gene discussed is VEGFA; the disease is neoplasm.