PSRC1 and metabolic syndrome: PSRC1 encodes the proline/serine‐rich coiled‐coil protein 1, which recruits microtubule depolymerases that destabilize microtubules.[48] In fact, PSRC1 has been identified as one of the top‐tier causal genes prioritized as potential therapeutic targets for dyslipidemia through multi‐omics and multi‐trait analyses.[23] Our study extended their finding in that we provided strong evidence from transcriptional and proteomic levels supporting the therapeutic potential of PSRC1 gene for CAD and identified its acting target as medium HDL.