PSRC1 and coronary artery disorder: However, previous GWA studies have reported risk loci of CAD at 1p13.3 near PSRC1, but no significant association was observed at this locus with IS risk,[61, 62, 63, 64] suggesting that the absence of similar therapeutic potential of PSRC1 for IS as for CAD might be more likely owing to their difference in pathological mechanisms.