CDH1 and neoplasm: In contrast, both 3D Ctrl and 3D sgECAD tumors were less sensitive to IKE (Figure 7A; Figure S13A–C, Supporting Information), and E‐cadherin deficiency further promoted tumor growth under IKE treatment (Figure 7A–C), suggesting that E‐cadherin deletion in 3D CRCs enhances the resistance to ferroptosis in vivo.