These approaches are often limited by poor compliance, adverse side effects (eg., gastrointestinal symptoms and nutritional deficiencies), and a failure to combat weight regain effectively.[70] In the present study, reduction of Chchd10 upon excess energy intake promotes adipogenesis in SAT in short‐term HFD feeding while protects against overall fat mass gain and metabolic disorders after long‐term HFD feeding by inducing GSTA4. This evidence concerns the gene GSTA4 and hyperinsulinemic hypoglycemia, familial, 4.