It is suggested that the overactive excretion of glutathionyl lipid aldehydes results in increased exposure of tissue‐resident macrophages to these inflammatory metabolites leading to insulin resistance.[75] Though Chchd10 KO mice do not show the neuromuscular degenerative phenotypes observed in patients with Chchd10 mutations,[76] Chchd2 and Chchd10 double KO mice exhibit cardiomyopathy and mitochondrial integrated stress response in the heart.[77] Thus, targeting Chchd10 may not contribute to neurodegenerative diseases but may potentially cause adverse effects in other organs. Here, CHCHD10 is linked to Insulin resistance.