Although studies of NRF2 in adipose tissue show conflicting results[54] as both inhibition and activation of NRF2 have been shown to suppress obesity and metabolic diseases, the present study reinforces the importance of Chchd10 reduction‐mediated NRF2 activation as an adaptive response in adipocytes in combating obesity and its related metabolic disorders. The gene discussed is NFE2L2; the disease is obesity disorder.