Taken together, the findings of fat pad weight gain and GSTA4 expression in ATC10‐OE mice are opposite to the phenotypes of ATC10‐KO mice subjected to a long‐term feeding model, which further confirms that Chchd10 reduction upon HFD feeding protects against diet‐induced adipose tissue dysfunction and obesity. The gene discussed is GSTA4; the disease is obesity due to melanocortin 4 receptor deficiency.