Although studies of NRF2 in adipose tissue show conflicting results[54] as both inhibition and activation of NRF2 have been shown to suppress obesity and metabolic diseases, the present study reinforces the importance of Chchd10 reduction‐mediated NRF2 activation as an adaptive response in adipocytes in combating obesity and its related metabolic disorders. This evidence concerns the gene CHCHD10 and obesity due to melanocortin 4 receptor deficiency.