GSTA4 and Insulin resistance: The expression levels of GSTA4 in adipose tissue are also negatively correlated with homeostatic model assessment of insulin resistance (HOMA‐IR).[19] GSTA4 deficiency leads to 4‐HNE accumulation and reduces the antioxidant capacity of mice.[38, 39] These findings highlight the clinical relevance of GSTA4 downregulation and adipose tissue dysfunction and reinforce the essential role of GSTA4 in eliminating 4‐HNE and maintaining antioxidant capacity in adipose tissue.