IRGM, a risk factor of Crohn's disease, directly interacts with NACHT domain of NLRP3, promotes the selective degradation of NLRP3 in p62‐dependent way, therefore inhibit the intestinal inflammation.[79] Here, we clarified that Ufl1‐mediated NLRP3 UFMylation prevents NLRP3 levels and inflammasome activation by suppressing autophagic degradation of NLRP3. Here, NLRP3 is linked to Crohn disease.