RNA modifications, especially ac4C, and its corresponding acetyltransferase, NAT10, have gained attention in various cancers, including GC.[10, 11] For example, it has been reported that NAT10‐mediated ac4C modification could promote GC progression by enhancing COL5A1 mRNA stability.[10c] Another study revealed that ac4C modification of NOTCH3 mRNA is a key regulatory switch for its function in esophageal squamous cell carcinoma metastasis.[10b] However, whether NAT10 and ac4C modification can regulate the progression of liver metastasis in patients with GC is still unknown. Here, COL5A1 is linked to esophageal squamous cell carcinoma.