It has been reported that NLRP3 activation and NLRP3‐mediated pyroptosis are closely related to the I/R‐induced cardiomyocyte injury and the aggravation of MI/RI,37 and inhibition of NLRP3 significantly alleviates MI/RI via down‐regulating cardiomyocyte pyroptosis.38 Here, NLRP3 is linked to myocardial infarction.