Previous studies of Echinococcus granulosus reported an immunosuppressive role of Spp1+ macrophages in cyst echinococcosis progression, which were expanded 6 months post infection and may be ineffective in parasite control.[46] Interestingly, our spatial data showed that the Spp1+ MoMFs were present soon after E. multilocularis infection (4 dpi) and may have been actively involved in pathogen‐killing since the early infection stage. Here, SPP1 is linked to infection.