Collectively, these results indicate that AS‐F‐NP effectively induces intense ICD in vivo, recruits CD8+ T cells to tumor nodes, and efficiently silences the upregulated Lat4 at the tumor nodes, demonstrating the potential of AS‐F‐NP to modulate immune response and overcome drug resistance by epigenetic intervene based on methionine restriction. Here, CD8A is linked to neoplasm.