Necroptosis was reported to be dynamically regulated by the NF‐κB/RelA signaling pathway.[25, 48] Moreover, our study on rheumatoid arthritis indicated that CD147 downregulation both increased the apoptotic rate and inhibited IKK/IκB kinase/NF‐κB pathway‐dependent proinflammatory cytokine secretion.[24] Therefore, we speculate that Mehozumab‐DM1 induces necroptosis by inhibiting the NF‐κB pathway. The gene discussed is RELA; the disease is rheumatoid arthritis.