Novel targets for solid tumors, particularly liver cancer, are yet to be discovered, and the molecular mechanisms of therapeutic drugs still require investigation.[30, 31] We previously demonstrated high levels of expression of the transmembrane protein CD147 in human HCC tissue, with a rate of positivity > 80%, which was significantly higher than in paracancerous tissue.[32] In this study, we found that CD147 gene expression was markedly increased in early‐stage HCC, suggesting CD147 as a potential biomarker for the early diagnosis of liver cancer. This evidence concerns the gene BSG and hepatocellular carcinoma.