STING also enhances ROS production.[30] ROS, as a product of intracellular oxidative stress, not only promotes cell senescence and ferroptosis[68] but also plays an important role in the proliferation and differentiation of tumor and non‐tumor stem cells.[69] For example, ROS promotes the osteogenic differentiation of diabetic tendon stem/progenitor cells.[70] Thus, ROS might be the key factor balancing in the STING regulation of ferroptosis and stem cell differentiation. This evidence concerns the gene STING1 and neoplasm.