Rheumatoid arthritis is an incurable inflammatory autoimmune disease that predominantly affects small joints.[1] Globally, the prevalence of RA is ≈0.5%, with a higher incidence in females, occurring two to three times more frequently than in males.[2] The progression of RA can be partitioned into three stages: an initial nonspecific inflammatory stage, a chronic inflammatory phase driven by T‐cell activation in the synovium, and a final tissue damage phase mediated by cytokines such as IL‐1, IL‐6, and TNF‐α. Here, IL1B is linked to rheumatoid arthritis.