TFEB and neurodegenerative disease: TFEB serves as the principal regulator of autophagy and facilitates the translocation of autophagy‐regulated genes upon nuclear entry.[54] Numerous studies have highlighted the significant effect of diminished nuclear localization of TFEB on neurodegenerative diseases and longevity.[55, 56] Our findings revealed decreased total protein levels in aged HEI‐OC1 cells, cochlear explants, and mouse cochleae (Figure 5G–L).