GCG and steatosis: However a concern for loss of lean mass has been raised due to glucagon‐induced hypoaminoacidemia, this might be prevented by protein supplementation which can defend lean mass at a glucagon dose of that is sub‐anorectic and does not reduce fat mass, but still reduce steatosis and glycemia in obese mice (Hope et al., 2022; Lopes et al., 2024).