Nevertheless, further investigations are needed to explore the link between NDPKB deficiency and metabolic abnormalities, in particular the activation of the endothelial HBP, to provide solid evidence for the inhibition of endothelial HBP activation in pre-diabetic and diabetic cardiomyopathy and NDPKB deficient conditions. Here, NME2 is linked to diabetic cardiomyopathy.