To further elucidate how PLS3 overexpression ameliorates SMA severity in a more relevant disease model in vivo, Ackermann et al. generated the “Taiwanese” SMA mouse model by overexpressing PLS3 fused with a V5 tag (SMAPLS3V5) in background strains of varying SMA disease severity. The gene discussed is PLS3; the disease is proximal spinal muscular atrophy.