In addition, protein expression analysis of BTG1, CCNG1, EDG1, and TIMP2 in MM tissues in mouse tumor masses treated with LNPs-anti-miR-503 confirmed the q-PCR results and the opposite expression of miR-503 and of its target genes also in vivo (Fig. 3A, B). The gene discussed is CCNG1; the disease is Miyoshi myopathy.