ABCB4 and liver disorder: A large-scale study [71] on the Icelandic population showed a strong correlation between some variants of ABCB4 and an increased risk of developing HBCs; the typical, non-pathogenic missense variant c.711A > T results associated with gallstones, ICP, cirrhosis, liver cancer, gallbladder cancer, and may represent a general risk factor for liver disease before 40 years.