Evidence collected via WES, WGS, and NGS [9] suggests a correlation between several genes implicated in the pathogenesis of PFIC, adult cholestasis (RIC, LPAC, ICP), and the risk of developing HCC and CCA in both children and adults: TJP2, FXR, MYO5B, SLC51B, SLC25A13, NOTCH2, JAG1, TGR5, ABCB11, ABCB4, and HNF1B [9]. Here, NOTCH2 is linked to hepatocellular carcinoma.