ABCB4 and gallbladder disease 1: Some PFIC gene variants in ABCB11, ABCB4, and TJP2 have been reported in patients with liver tumors; these data strongly suggest that subjects with idiopathic chronic cholestasis and personal or familial risk factors for inherited cholestasis, as well as DIC, ICP, or LPAC history, should be screened for a panel of primary cholestasis-related genes.