Previous studies highlighted CYFIP1 served as the member of WRC complexes and CYFIP1-EIF4E-FMR1 complexes, broadly involving in the cytoskeletal dynamics and protein translation of various cancers(Rubeis et al. 2013; Marino et al. 2015; Teng et al. 2016a, b; Silva et al. 2009). Here, EIF4E is linked to cancer.