RNMT and Williams syndrome: To date, despite limited research on m7G modification, multiple regulators with m7G methyltransferase activities have been identified, including Methyltransferase 1, TRNA Methylguanosine / WD Repeat Domain 4 (METTL1/WDR4), Williams-Beuren Syndrome Chromosomal Region 22 / TRNA Methyltransferase Activator Subunit 11 − 2 (WBSCR22/TRMT112), RNA Guanine-7 Methyltransferase / RNA Guanine-7 Methyltransferase Activating Subunit (RNMT/RAM)(Luo et al. 2022; Xia et al. 2023; Chen et al. 2021; Alexandrov et al. 2002), which provides directions for research on m7G modification.