Mice with a knockout of Abca4 and Rdh8 genes (Abca4−/−Rdh8−/− mice) reproduce primary features of STGD1 and dry AMD, including the deterioration of photoreceptors and the RPE as well as the accumulation of all-trans-retinal condensation products [11]. This evidence concerns the gene RDH8 and dry age related macular degeneration.