m6A-regulatory enzymes, known as readers, which are proteins responsible for activating downstream m6A signaling, were also found to be altered: YTH N6-methyladenosine RNA-binding protein (Ythd) C1 (Ythdc1) and Ythdc2 were increased after FTO inhibition, while Ythdf1, Ythdf2 and Ythdf3 decreased (Fig. 6B), suggesting a complex reorganization of m6A-dependent RNA regulation, that may have implications for various cellular processes and neurodegenerative diseases. The gene discussed is YTHDF3; the disease is neurodegenerative disease.