ATM and cancer: To validate this option, recently an English study by T. Mukhtar et al. analyzed retrospectively and prospectively the associations between cancers and coding variants in ATM using whole-exome sequence data from UK Biobank (348 488 participants) and showed that the combined Relative Risk (RR) for protein-truncating variants (PTVs) in ATM and ovarian cancer was 3.2 [38].