Next-generation sequencing (NGS) was performed on the original tumor (block obtained from her home institution) and was negative for BRAF, KIT, NF1, and NRAS mutations, with homozygous loss of exon 3 of PTEN (chr10q), whole arm loss of chr6q, and detection of multiple coding variants, including both known pathogenic variants and variants of unknown significance (VUS) (Table 1). This evidence concerns the gene PTEN and neoplasm.