INS and Insulin resistance: No significant differences were identified for metabolic parameters (P > 0.05; Table 1), including peripheral insulin sensitivity based on the oral glucose tolerance test (oGTT)-derived Matsuda Index and the homeostasis model assessment insulin resistance (HOMA-IR), as well as inflammatory markers such as C-reactive protein (CRP), interleukin (IL)-6 (Table 1) and other cytokines (Extended Data Table 3).