ERBB3 and neoplasm: These findings compared favourably against S2Ga alone, which lacks cell membrane permeability33, and against the non-targeted clinically used chemotherapy agent liposomal doxorubicin (lipodox or Doxil), which serves here as a benchmark for therapeutic efficacy but showed toxicity on both HER3+ tumour cells and HER3− fibroblasts (Fig. 1k).