CDC27 and Miyoshi myopathy: To elucidate the underlying mechanism of CDC27 O-GlcNAcylation in modulating MM cell function, firstly, we observed the increased CDC27 mRNA levels in OSMI-1-treated MM cells but reduced levels in Thiamet G MM cells, which is contrary to the protein level changes in MM cells (Fig. 4a), indicating the protein levels of CDC27 were crucially modulated at the post-transcriptional levels.