TLR4 and liver disorder: On mRNA level, no changes in Integrin alpha M (Itgam), Tissue inhibitor of metalloproteinase 1 (Timp1) and Toll- like receptor 4 (Tlr4), known markers of oxidative stress in liver disease, were detectable neither at P21 nor in late adulthood (Supplementary Fig. S4e,f)26.