LGI1 and Epileptic encephalopathy: This observed qualitative and quantitative EEG change reflects the natural history of LGI1 autoantibody-associated seizures observed in one of the first-described patient cohorts that presented with an increasing frequency of facio-brachial dystonic seizures until they reached a maximum at the onset of epileptic encephalopathy/limbic encephalitis (Binks et al., 2018; Irani et al., 2011).