Variants in the CFH-CFHR5 extended region (Chr1-associated AMD locus) and ARMS2/HTRA1 region (Chr10-associated AMD locus) (Pappas et al., 2021) account for approximately 70% of the variability in AMD explained by genetic effects (Fritsche et al., 2016), and close to 90% of individuals with AMD carry at least one risk allele at one of these loci (Colijn et al., 2021; Pappas et al., 2021). Here, ARMS2 is linked to age-related macular degeneration.