HTRA1 and age-related macular degeneration: Genetic analysis has led to the identification of three main pathways implicated in AMD: complement (CFH-CFHR5, C2/CFB, CFI, C3, TMEM97/VTN), lipid homeostasis (APOE, LIPC, CETP), and extracellular matrix remodeling (COL4A3, COL8A1, SYN3/TIMP3, VEGFA ADAMTS9-AS2, ARMS2/HTRA1) (Colijn et al., 2021; Fritsche et al., 2016) (See also https://www.sciencedirect.com/journal/experimental-eye-research/vol/254/suppl/C Genomics paper in this special issue).